4단계 BK21-2차년도 논문성과

17. An. H.J., Kim, Y., Chang, S. Kim. HC, Song J, Park H, Choi I High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes. Nat Commun. 2021 Oct 8;12(1):5899. doi: 10.1038/s41467-021-26224-9.

16. Prasad R, Jung W, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, and Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in the patients of Alzheimer’s disease. Scientific Rep. 2021 Oct 8;11(1):20075. doi: 10.1038/s41598-021-99562-9.

15. Jeong W, Jho EH. Regulation of the low-density lipoprotein receptor-related protein LRP6 and its association with disease: Wnt/β-catenin signaling and beyond. Front. Cell Dev. Biol. 2021 Sep 13;9:714330. doi: 10.3389/fcell.2021.714330 eCollection 2021.

14. Han B*, Jung BK*, Park SH, Song KJ, Anwar MA, Ryu KY# and Kim KP#. Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development. Cell Death Discovery 2021 July 26th 7:194 ; doi: doi.org/10.1038/s41420-021-00581-2 (published online) (*These two authors have equal contributions to this paper. #Co-corresponding author)

13. Lim SA, Moon Y, Shin MH, Kim TJ, Chae S, Yee C, Hwang D, Park H*, Lee KM*. Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways. Cancers (Basel). 2021 Apr 15;13(8):1904. doi: 10.3390/cancers13081904. (*, Co-corresponding authors)

12. Razia S, Park H, Shin E, Shim KS, Cho E, Kim SY. Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies. Molecules. 2021 Apr 30;26(9):2626. doi: 10.3390/molecules26092626.

11. Shin Y, Whang K, Hwang JH, Jo Y, Choi JW, Park J, Choi I, Kang T. Sensitive and Direct Optical Monitoring of Release and Cellular Uptake of Aqueous CO from CO-Releasing Molecules. Jul 20;93(28):9927-9932. doi: 10.1021/acs.analchem.1c02216. Epub 2021 Jul 8.

10. Park CW, Ryu KY. Free ubiquitin: a novel therapeutic target for neurodegenerative diseases. Neural Regen Res, 16(9): 1781–1782, 2021 Sep 1. doi:10.4103/1673-5374.306075

9. Kwon H, Kim J, Jho EH. Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ. 2022 Oct;289(19):5798-5818. doi: 10.1111/febs.16091. Epub 2021 Jul 13. PMID: 34173335

8. Park EJ, Kim SN, Yoon C, Cho JW, Lee GH, Kim DW, Park J, Choi I, Lee SH, Song J, Lim HJ, Kang MS, Lee HS. Repeated intratracheal instillation of zinc oxide nanoparticles induced pulmonary damage and a systemic inflammatory response in cynomolgus monkeys. Nanotoxicology. 2021 Jun;15(5):621-635. doi: 10.1080/17435390.2021.1905899.

7. Han SW, Jung BK, Ryu KY. Regulation of polyubiquitin genes to meet cellular ubiquitin requirement. BMB Rep, 54(4): 185–195, 2021 Apr 30. doi: 10.5483/BMBRep.2021.54.4.005

6. Tan A, Prasad R and Jho EH. TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy-lysosomal Biogenesis. Cell Death Dis. 2021 Apr 1;12(4):343. doi: 10.1038/s41419-021-03632-9.

5. Park J, Lee S, Choi J, Choi I. Extra- and Intracellular Monitoring of TGF-β Using Single Immunoplasmonic Nanoprobes. ACS Sens. 2021 May 28;6(5):1823-1830. doi: 10.1021/acssensors.0c02723.

4. Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1.  Cell Death Differ. 2021 Sep;28(9):2555-2570. doi: 10.1038/s41418-021-00770-7.

3. Jang J, Song J, Lee H, Sim I, Kwon YV, Jho EH*, and Yoon Y*. LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways. Exp Mol Med. 2021 Mar;53(3):407-421. doi: 10.1038/s12276-021-00577-z. (*, Co-corresponding authors)

2. Kwon O, Song J, Yang Y, Kim S, Kim J, Seok M, Hwang I, Yu J, Jenisha K, Maeng H, Kim J, Jho EH, Ko S, Ko S, Son H, Chang M, Lee S. 2021. SGK1 inhibition in glia ameliorates pathologies and symptoms of Parkinson's disease. EMBO Mol Med. 2021 Apr 9;13(4):e13076. doi: 10.15252/emmm.202013076.

1. Han SW, Choi J, Ryu KY. Stress response of mouse embryonic fibroblasts exposed to polystyrene nanoplastics. Int J Mol Sci, 22(4): 2094, 2021 Feb 20. doi:doi.org/10.3390/ijms22042094

4단계 BK21 -1차년도 논문성과

6. Park CW, Bae JS, Ryu KY. Simultaneous Disruption of Both Polyubiquitin Genes Affects Proteasome Function and Decreases Cellular Proliferation. Cell Biochem Biophys. 2020 Sep;78(3):321-329. doi: 10.1007/s12013-020-00933-2. Epub 2020 Jul 23.

5. Jung BK, Han SW, Park SH, Bae JS, Choi J, Ryu KY. Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain. Neurotoxicology. 2020 Dec;81:189-196. doi: 10.1016/j.neuro.2020.10.008. Epub 2020 Oct 24.

4. Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH. LDL receptor-related protein LRP6 senses nutrient levels and regulates Hippo signaling. EMBO Rep. 2020 Sep 3;21(9):e50103. doi: 10.15252/embr.202050103. Epub 2020 Aug 7.

3. Lee EJ, Seo E, Kim JW, Nam SA, Lee JY, Jun J, Oh S, Park M, Jho EH, Yoo KH, Park JH, Kim YK. TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29001-29012. doi: 10.1073/pnas.2009334117. Epub 2020 Oct 29.

2. Moon Y, Moon R, Roh H, Chang S, Lee S, Park H. HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells. Mol Cells. 2020 Nov 30;43(11):945-952. doi: 10.14348/molcells.2020.0100.

1. Moon Y, Kim I, Chang S, Park B, Lee S, Yoo S, Chae S, Hwang D, Park H. Hypoxia regulates allele-specific histone modification of the imprinted H19 gene. Biochim Biophys Acta Gene Regul Mech. 2020 Nov;1863(11):194643. doi: 10.1016/j.bbagrm.2020.194643. Epub 2020 Oct 7.

4단계 BK21 -1차년도 특허 성과

Inhee Choi, Seungki Lee

플라스몬 나노입자가 자발적으로 임베딩된 하이브리드젤 입자의 원-포트 합성방법 및 이를 이용한 광열 반응 기반 약물전달 방법

(Methods for one-pot synthesis of hybridgel particles with self-embedded plasmonic nanoparticles and its application to photothermal drug delivery) Korean Patent No. 10-2221924, 2021.02.24 (Korean Patent Application No. 10-2019-0106886, 2019.8.29)

Inhee Choi, Chang Min Jin, Tae Ho Kang

금속 나노입자를 이용하여 CMIT/MIT를 정량 및 정성적으로 분석하기 위한 광학 검출방법

(Optical detection methods for quantitative and qualitative analyses of CMIT/MIT using metal nanoparticles) Korean Patent No. 10-2219329, 2021.02.17 (Korean Patent Application No. 10-2019-0090178, 2019.7.25)

Inhee Choi, Junhee Park, Seungki Lee

세포내외 바이오마커의 고감도 검출을 위한 싱글 플라즈몬 금속나노입자 센서

(Single plasmonic metal nanoparticle sensor for highly sensitive detection of intra and extracellular biomarker) Korean Patent Application No. 10-2021-0006455 (2021.01.18)