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2021년 4월 본 연구진[교신저자: 조익훈 교수, 공동제1저자: Anderson tan, Renuka Prasad(신진연구인력)]에서 Cell Death & Disease 에 발표한


"TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy-lysosomal biogenesis"

이 CDDpress에 4월 게재된 논문 중 Monthly Top Picks 에 선정됨.




  • BK Team

최종 수정일: 2023년 2월 19일

17. An. H.J., Kim, Y., Chang, S. Kim. HC, Song J, Park H, Choi I High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes. Nat Commun. 2021 Oct 8;12(1):5899. doi: 10.1038/s41467-021-26224-9.


16. Prasad R, Jung W, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, and Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in the patients of Alzheimer’s disease. Scientific Rep. 2021 Oct 8;11(1):20075. doi: 10.1038/s41598-021-99562-9.


15. Jeong W, Jho EH. Regulation of the low-density lipoprotein receptor-related protein LRP6 and its association with disease: Wnt/β-catenin signaling and beyond. Front. Cell Dev. Biol. 2021 Sep 13;9:714330. doi: 10.3389/fcell.2021.714330 eCollection 2021.


14. Han B*, Jung BK*, Park SH, Song KJ, Anwar MA, Ryu KY# and Kim KP#. Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development. Cell Death Discovery 2021 July 26th 7:194 ; doi: doi.org/10.1038/s41420-021-00581-2 (published online) (*These two authors have equal contributions to this paper. #Co-corresponding author)


13. Lim SA, Moon Y, Shin MH, Kim TJ, Chae S, Yee C, Hwang D, Park H*, Lee KM*. Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways. Cancers (Basel). 2021 Apr 15;13(8):1904. doi: 10.3390/cancers13081904. (*, Co-corresponding authors)


12. Razia S, Park H, Shin E, Shim KS, Cho E, Kim SY. Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies. Molecules. 2021 Apr 30;26(9):2626. doi: 10.3390/molecules26092626.


11. Shin Y, Whang K, Hwang JH, Jo Y, Choi JW, Park J, Choi I, Kang T. Sensitive and Direct Optical Monitoring of Release and Cellular Uptake of Aqueous CO from CO-Releasing Molecules. Jul 20;93(28):9927-9932. doi: 10.1021/acs.analchem.1c02216. Epub 2021 Jul 8.


10. Park CW, Ryu KY. Free ubiquitin: a novel therapeutic target for neurodegenerative diseases. Neural Regen Res, 16(9): 1781–1782, 2021 Sep 1. doi:10.4103/1673-5374.306075


9. Kwon H, Kim J, Jho EH. Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ. 2022 Oct;289(19):5798-5818. doi: 10.1111/febs.16091. Epub 2021 Jul 13. PMID: 34173335


8. Park EJ, Kim SN, Yoon C, Cho JW, Lee GH, Kim DW, Park J, Choi I, Lee SH, Song J, Lim HJ, Kang MS, Lee HS. Repeated intratracheal instillation of zinc oxide nanoparticles induced pulmonary damage and a systemic inflammatory response in cynomolgus monkeys. Nanotoxicology. 2021 Jun;15(5):621-635. doi: 10.1080/17435390.2021.1905899.


7. Han SW, Jung BK, Ryu KY. Regulation of polyubiquitin genes to meet cellular ubiquitin requirement. BMB Rep, 54(4): 185–195, 2021 Apr 30. doi: 10.5483/BMBRep.2021.54.4.005


6. Tan A, Prasad R and Jho EH. TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy-lysosomal Biogenesis. Cell Death Dis. 2021 Apr 1;12(4):343. doi: 10.1038/s41419-021-03632-9.


5. Park J, Lee S, Choi J, Choi I. Extra- and Intracellular Monitoring of TGF-β Using Single Immunoplasmonic Nanoprobes. ACS Sens. 2021 May 28;6(5):1823-1830. doi: 10.1021/acssensors.0c02723.

4. Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1.  Cell Death Differ. 2021 Sep;28(9):2555-2570. doi: 10.1038/s41418-021-00770-7.

3. Jang J, Song J, Lee H, Sim I, Kwon YV, Jho EH*, and Yoon Y*. LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways. Exp Mol Med. 2021 Mar;53(3):407-421. doi: 10.1038/s12276-021-00577-z. (*, Co-corresponding authors)

2. Kwon O, Song J, Yang Y, Kim S, Kim J, Seok M, Hwang I, Yu J, Jenisha K, Maeng H, Kim J, Jho EH, Ko S, Ko S, Son H, Chang M, Lee S. 2021. SGK1 inhibition in glia ameliorates pathologies and symptoms of Parkinson's disease. EMBO Mol Med. 2021 Apr 9;13(4):e13076. doi: 10.15252/emmm.202013076.


1. Han SW, Choi J, Ryu KY. Stress response of mouse embryonic fibroblasts exposed to polystyrene nanoplastics. Int J Mol Sci, 22(4): 2094, 2021 Feb 20. doi:doi.org/10.3390/ijms22042094



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