분자세포생리학 실험실
박현성 Hyunsung Park Ph.D.
Address : The University of Seoul
Department of Life Science
163 Seoulsiripdae-ro, Dongdaemun-gu
Seoul, 02504, Korea
E-mail : hspark@uos.ac.kr
homepage : https://lifesci.uos.ac.kr/mcpl
Education:
Ph.D., School of Medicine, Stanford University (Molecular Pharmacology)
M.S., Graduate School of Pharmacy, Seoul National University (Pharmaceutical Bioscience)
B.A., College of Pharmacy, Seoul National University
Experiences:
2008 - present, Professor, in Dept of Life Science, College of Natural Science, University of Seoul
2003 - 2008, Associate Professor in Dept of Life Science, College of Natural Science, University of Seoul
1997 - 2003, Assistant Professor in Dept of Life Science, College of Natural Science, University of Seoul
1992 - 1997, Research Assistant, in Dept of Molecular Pharmacology, Stanford Medical School
1989 - 1991, Research Assistant, in Dept of Biochemistry and Biophysics, Texas A&M University
Professional Appointments
2010 - present editorial board of BMB reports
2014 - present Chairperson of organizing committee of annual symposium of Korean Federation of Women’s Science and technology associations
Latest Research
2022
Moon Y, Chae S, Yim S, Yang EG, Choe J, Hyun J, Chang R, Hwang D, Park H.
Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia.
iScience. 2022 Jun 3;25(7):104517. doi: 10.1016/j.isci.2022.104517. PMID: 35754713; PMCID: PMC9218365.
Razia S, Park H, Shin E, Shim KS, Cho E, Kang MC, Kim SY.J
Ethnopharmacol. 2022 May 23;290:115096. doi: 10.1016/j.jep.2022.115096. Epub 2022 Feb 17.PMID: 35182666
Lee GJ, Kim YJ, Park B, Yim S, Park C, Roh H, Moon Y, Seong JK, Park H.
YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity.
Cell Death Dis. 2022 Apr 27;13(4):407. doi: 10.1038/s41419-022-04847-0.PMID: 35478181
Gold and silver plasmonic nanoprobes trace the positions of histone codes.
BMB Rep. 2022 Mar;55(3):111-112. doi: 10.5483/BMBRep.2022.55.3.004.PMID: 35000676
2021
Lim SA, Moon Y, Shin MH, Kim TJ, Chae S, Yee C, Hwang D, Park H*, Lee KM.
Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways.
Cancers (Basel). 2021 Apr 15;13(8):1904. doi: 10.3390/cancers13081904. PMID: 33920906; PMCID: PMC8071270. (*, Co-corresponding authors)
Razia S, Park H, Shin E, Shim KS, Cho E, Kim SY.
Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies.
Molecules. 2021 Apr 30;26(9):2626. doi: 10.3390/molecules26092626. PMID: 33946287; PMCID: PMC8125160.
An HJ, Kim Y, Chang S, Kim H, Song J, Park H*, Choi I.
High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes.
Nat Commun. 2021 Oct 8;12(1):5899. doi: 10.1038/s41467-021-26224-9. PMID: 34625566; PMCID: PMC8501099. (*, Co-corresponding authors)
2020
Moon Y, Kim I, Chang S, Park B, Lee S, Yoo S, Chae S, Hwang D, Park H.
Hypoxia regulates allele-specific histone modification of the imprinted H19 gene.
Biochim Biophys Acta Gene Regul Mech. 2020 Nov;1863(11):194643. doi: 10.1016/j.bbagrm.2020.194643. Epub 2020 Oct 7. PMID: 33035707.
Moon Y, Moon R, Roh H, Chang S, Lee S, Park H.
HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells.
Mol Cells. 2020 Nov 30;43(11):945-952. doi: 10.14348/molcells.2020.0100. PMID: 33203807; PMCID: PMC7700838.
2019
Chang S, Yim S, Park H.
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Exp Mol Med. 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981; PMCID: PMC6586683.
Park B, Chang S, Lee GJ, Kang B, Kim JK, Park H.
Wnt3a disrupts GR-TEAD4-PPARγ2 positive circuits and cytoskeletal rearrangement in a β-catenin-dependent manner during early adipogenesis.
Cell Death Dis. 2019 Jan 8;10(1):16. doi: 10.1038/s41419-018-1249-7. PMID: 30622240; PMCID: PMC6325140.
2018
Moon Y, Lee S, Park B, Park H.
Distinct hypoxic regulation of preadipocyte factor-1 (Pref-1) in preadipocytes and mature adipocytes.
Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):334-342. doi: 10.1016/j.bbamcr.2017.11.008. Epub 2017 Nov 11. PMID: 29138005.
2017
Lee S, Lee J, Chae S, Moon Y, Lee HY, Park B, Yang EG, Hwang D, Park H.
Multi-dimensional histone methylations for coordinated regulation of gene expression under hypoxia.
Nucleic Acids Res. 2017 Nov 16;45(20):11643-11657. doi: 10.1093/nar/gkx747. PMID: 28977425; PMCID: PMC5714201.
BK21 supported members
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지원
Chansang Park
Project :
Estimation of mouse biological age using quatification of DNA methylation
Younggeun Yoo
Project :
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참여
