세포신호전달 실험실
조익훈 Eek-hoon Jho, Ph.D.
Address : The University of Seoul
Department of Life Science
163 Seoulsiripdae-ro, Dongdaemun-gu
Seoul, 02504, Korea
E-mail : ej70@uos.ac.kr
Homepage:
https://cstl8503.wixsite.com/wnthippo
Education:
Seoul National University(Seoul,Korea) B.S. 1986 Agri-chemistry
Hanyang University (Seoul,Korea) M.S. 1989 Genetic Engineering
Michigan State University (E.Lansing) Ph.D. 1995 Molecular biology
Experiences:
Michigan State University 1990.9 - 1995.10 Teaching Assistant
SUNY at Stony Brook 1995.11 - 1997.2 Post-doctoral Research Scientist
Columbia University (New York) 1997.3 - 2000.12 Associate Research Scientist
The University of Seoul 2001.9 - present Professor
University of Southern California 2007.12 - 2008.12 Visiting Scholar
Latest Research
2023
Thao Thi Dang, Mi-Jeong Kim, Yoon Young Lee, Hien Thi Le, Kook Hwan Kim, Somi Nam, Seung Hwa Hyun, Hong Lim Kim, Su Wol Chung, Hun Taeg Chung, Jho EH, Hiderou Yoshida, Kyoungmi Kim, Chan Young Park, Myung-Shik Lee, Sung Hoon Back. Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress. Autophagy. 2023 Jan 31. doi: 10.1080/15548627.2023.2173900. Online ahead of print.
2022
Lee J, Kim E, Kang MK, Ryu J, Kim JE, Shin EA, Pinanga Y, Pyo KH, Lee H, Lee EH, Cho H, Cheon J, Kim W, Jho EH, Kim S, Lee JW. Systemic TM4SF5 overexpression in Apc Min/+ mice promotes hepatic portal hypertension associated with fibrosis. BMB Rep. 2022 Dec;55(12):609-614. doi: 10.5483/BMBRep.2022.55.12.104.
Kim E, Kang JG, Jho EH, Yang WH, Cho JW. O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway. Cancers (Basel). 2022 Jun 18;14(12):3013. doi: 10.3390/cancers14123013.
Tan A*, Prasad R*, Lee C, and Jho EH. Past, Present, and Future Perspectives of Transcription Factor EB (TFEB): Mechanisms of regulation and association with disease. Cell Death Differ. 2022 Aug;29(8):1433-1449. doi: 10.1038/s41418-022-01028-6.
Lee U, Cho E, Jho EH. Regulation of Hippo signaling by metabolic pathways in cancer. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119201. doi: 10.1016/j.bbamcr.2021.119201.
2021
Prasad R, Jung W, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, and Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in the patients of Alzheimer’s disease. Scientific Rep. 2021 Oct 8;11(1):20075. doi: 10.1038/s41598-021-99562-9.
Jeong W, Jho EH. Regulation of the low-density lipoprotein receptor-related protein LRP6 and its association with disease: Wnt/β-catenin signaling and beyond. Front. Cell Dev. Biol. 2021 Sep 13;9:714330. doi: 10.3389/fcell.2021.714330. eCollection 2021.
Kwon H, Kim J, Jho EH. Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ. FEBS J. 2022 Oct;289(19):5798-5818.
2021 Jun 26. doi: 10.1111/febs.16091.
Tan A, Prasad R and Jho EH. TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy-lysosomal Biogenesis. Cell Death Dis. 2021 Apr 1;12(4):343. doi: 10.1038/s41419-021-03632-9.
● This work has been selected by "CDDpress: Our Monthly Top Picks"
Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH. PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1. Cell Death Differ. 2021 Sep;28(9):2555-2570. doi: 10.1038/s41418-021-00770-7.
Jang J, Song J, Lee H, Sim I, Kwon YV, Jho EH*, and Yoon Y*. LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways. Exp Mol Med. 2021 Mar;53(3):407-421. doi: 10.1038/s12276-021-00577-z. (*, Co-corresponding authors)
Kwon O, Song J, Yang Y, Kim S, Kim J, Seok M, Hwang I, Yu J, Jenisha K, Maeng H, Kim J, Jho EH, Ko S, Ko S, Son H, Chang M, Lee S. 2021. SGK1 inhibition in glia ameliorates pathologies and symptoms of Parkinson's disease. EMBO Mol Med. 2021 Apr 9;13(4):e13076. doi: 10.15252/emmm.202013076.
2020
Lee EJ, Seo E, Kim JW, Nam SA, Lee JY, Jun J, Oh S, Park M, Jho E, Yoo KH, Park JH, Kim YK. (2020) TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A. 117(46):29001-29012.
Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH. 2020. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling. EMBO Reports 21(9):e50103
● A commentary for this work was presented in “News & Views” in EMBO reports.
● This work has been recommended in Faculty Opinions.
Kim S, Kim H, Tan A, Song Y, Lee H, Ying QL, Jho EH. 2020. The distinct role of Tcfs and Lef1 in the self-renewal or differentiation of mouse embryonic stem cells. Int J Stem Cells. 13(2):192-201.
Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W*, Jho EH*. 2020. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis. Proc Natl Acad Sci U S A. 117(24):13529-13540. (*, Co-corresponding authors)
Kim E, Kang JG, Kang MJ, Park JH, Kim YJ, Kim Y, Kweon TH, Lee HW, Jho EH, Lee Y, Kim SI, Yi EC, Park HW, Yang WH, Cho JW. 2020. O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity. Proc Natl Acad Sci U S A. 117(25):1459-14269.
2019
Prasad R and Jho EH. 2019. A Concise Review of Human Brain Methylome During Aging and Neurodegenerative Diseases. BMB Rep. 52(10):577-588.
Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, Yang Y. 2019. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proc Natl Acad Sci U S A. 116(19):9423-9432.
2018
Jho EH. 2018. Dual role of YAP: oncoprotein and tumor suppressor. J.Thoracic Dis. 10, S3895-S3898.
Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS. 2018. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling. Cell Rep. 25(3):571-584.
Song Y, Lee S, Kim JR, Jho EH. 2018. Pja2 inhibits Wnt/β-catenin signaling by reducing the level of TCF/LEF1. Int J Stem Cells.11(2):242-247.
Chung H, Jung H, Jho EH, Multhaupt HAB, Couchman JR, Oh ES. 2018. Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation. BBRC 503(2):615-620.
Song Y, Lee S, Jho EH. 2018. Enhancement of neuronal differentiation by using small molecules modulating Nodal/Smad, Wnt/β-catenin, and FGF signaling. BBRC 503(1):352-358.
Lee H, Lee E, Seo J, Jeong M, Lee S, Kim SY, Jho E, Choi CH, Chung J, Song J. 2018. Ubiquitylation and degradation of Adenomatous Polyposis Coli by MKRN1 enhances Wnt/β-catenin Signalling. Oncogene 37(31):4273-4286.
Jho EH. 2018. Hippo signaling: Special issue of BMB Reports in 2018. BMB Rep. 51(3):105.
Kim W, Jho EH. 2018. The history and regulatory mechanism of the Hippo pathway. BMB Rep. 51(3):106-118.
Kim Y, Jho EH. 2018. Regulation of the Hippo Signaling Pathway by Ubiquitin Modification. BMB Rep. 51(3):143-150.
Park J, Jung H, Kim K, Lim KM, Kim JY, Jho EH, Oh ES. 2018. D-tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity. Pigment Cell Melanoma Res. 31(3):374-383
2017
Moon S, Kim J, Jho E. 2018. In vitro NLK Kinase Assay. Bio-Protocol 7(21):1-10.
Kang DH, Lee DJ, Lee S, Lee SY, Jun Y, Kim Y, Kim Y, Lee JS, Lee DK, Lee S, Jho EH, Yu DY, Kang SW. 2017. Interaction of Tankyrase and Peroxiredoxin II is Indispensable for the Survival of Colorectal Cancer Cells. Nat Comm. 8(1):40.
Kim Y, Jho EH. 2017. Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer. BMB Reports 50(6):281-282.
Ji L, Bishayee K, Sadra A, Choi S, Choi W, Moon S, Jho EH, Huh SO. 2017. Defective neuronal migration and inhibition of bipolar to multipolar transition of migrating neural cells by Mesoderm-Specific Transcript, Mest, in the developing mouse neocortex. Neuroscience 355:126-140.
Kim Y, Kim W, Song Y, Kim JR, Cho K, Moon H, Ro SW, Seo E, Ryu YM, Myung SJ, Jho EH. 2017. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 114:4691-4696.
● Highlighted in Hepatic cell news – April 21, 2017
Cho S, Cha B, Kwon O, Lim J, Shin D, Han D, Ishitani T, Jho EH, Fornace AJ, Cha H. 2017. Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development. BBA-Mol. Basis of Disease 330:157-164.
Jang J, Jung Y, Kim Y, Jho EH*, Yoon YS*. 2017. LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974, in bronchial epithelial cells . Scientific reports 7:41612. (*, Co-corresponding authors)
Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev VL , Jho EH. 2017. Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. EMBO reports. 18(1):61-71.
● A commentary for this work was presented in “News & Views” in EMBO reports.
● F1000Prime Recommendations, In F1000Prime, 20 Feb 2017; F1000Prime.com/727114897
● EMBO encounters Issue35, Spring 2017. P.19. Selected as a representative paper among published
Papers in EMBO Reports during the Spring of 2017.
Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. 2017. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO reports. 18(1):72-86.
Kim W, Kahn SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y. 2017. Interacting network of Hippo, Wnt/b-catenin and Notch signaling represses liver tumor formation. J Clin Invest. 127(1):137-152.
2016
Kim S, Jho EH. 2016. Merlin, a regulator of Hippo signaling, regulates Wnt/b-catenin signaling. BMB Rep. 49:357-8.
Cha B, Geng X, Mahmud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon B, Chen H, Srinivasan RS. 2016. Mechanotransduction activates Canonical Wnt/b-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes & Dev. 30(12):1454-69.
Kim M, Kim S, Lee SH, Kim W, Sohn MJ, Kim HS, Kim J*, Jho EH*. 2016. Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation. Cell Death and Diff. 23(10):1638-47.(*, Co-corresponding authors)
2015
Shin DW, Sohn MJ, Kim HS, Lee DJ, Jeon SR, Hwang YJ, Jho EH. 2015. Clinical analysis of spinal stereotactic radiosurgery in the treatment of neurogenic tumors. J Neurosurg Spine. 23(4):429-37.
Kim H, Kim S, Song Y, Kim W, Ying QL, Jho EH. 2015. Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015:459301.
Cha B, Park Y, Hwang BN, Kim SY, Jho EH. 2015. Protein Arginine Methyltransferase 1 Methylates Smurf2. Mol Cells. 38(8):723-8.
BK21 supported members
-
지원
SAEROM CHA
Project
: O-GlcNAcylation in Wnt signaling
Md Intazur Rahaman
Project
: Potential involvement of differentially expressed secretome in organ size determination
HYEWON SHIM
Project
: A novel regulator of Hippo signaling
CHAELIN LEE
Project
: Regulation of Transcription factor EB in Wnt signaling pathway
EUNYEOUNG YANG
Project
: Research for moonlighting proteins associated with Hippo signaling components
-
참여
EUNYOUNG CHO
Project
: Identification of novel molecules interacting with Hippo pathway component
YUNHO CHOI
Project
: Identifying novel regulatory mechanisms of Wnt signaling in Alzheimer's disease
Other members
Ukjin Lee
Project
: Identification of O-GlcNAcylated novel molecule in Wnt and hippo signaling
