바이러스면역학 실험실
이정현 Jung-hyun Lee, Ph.D.
Address : The University of Seoul
Department of Life Science
163 Seoulsiripdae-ro, Dongdaemun-gu
Seoul, 02504, Korea
E-mail : jhlee1@uos.ac.kr
Homepage:
https://lifesci.uos.ac.kr/jhlab_vil
Education:
Ewha Womans University(Seoul,Korea) B.S. 2006 Life Sciences
Ewha Womans University (Seoul,Korea) M.S. 2008 Cancer biology
Friedrich-Alexander-University Erlangen-Nürnberg (Erlangen,Germany) Ph.D. 2014 Molecular virology, Cancer Biology
Experiences:
Universitätsklinikum Erlangen 2014.03 - 2016.09 Post-doctoral Researcher
Universitätsklinikum Erlangen 2016.10 - 2018.04 Leader of junior group
The University of Chicago 2018.05 - 2020.06 Post-doctoral Researcher
Cleveland Clinic Florida 2020.07 - 2020.12 Research professor
Ulm University 2021.02 - 2022.02 Leader of junior group
University of Seoul 2022.03 - present Assistant professor
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Latest Research
2024
Woosung shim, Anjae Lee, Lee JH. The role of extracellular vesicles in pandemic viral infections. Journal of Microbiology. 2024 Jun;62(6):419-427. doi: 10.1007/s12275-024-00144-x Epub 2024 Jun 25. PMID: 38916789
2023
Lee JH. The complex role of extracellular vesicles in HIV infection. BMB Rep. 2023 Jun;56(6):335-340. doi: 10.5483/BMBRep.2023-0073. PMID: 37291055; PMCID: PMC10315562.
Xie Q, Bozzo CP, Eiben L, Noettger S, Kmiec D, Nchioua R, Niemeyer D, Volcic M, Lee JH, Zech F, Sparrer KMJ, Drosten C, Kirchhoff F. Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2. iScience. 2023 Apr 21;26(4):106395. doi: 10.1016/j.isci.2023.106395. Epub 2023 Mar 13. PMID: 36968088; PMCID: PMC10009997.
Lee JH, Koepke L, Kirchhoff F, Sparrer KMJ. Interferon antagonists encoded by SARS-CoV-2 at a glance. Med Microbiol Immunol. 2023 Apr;212(2):125-131. doi: 10.1007/s00430-022-00734-9. Epub 2022 Apr 2. PMID: 35366686; PMCID: PMC8976456.
2022
Kim SY, Borner U, Lee JH, Wagner F, Tshering Vogel DW. Magnetic resonance imaging of parotid gland tumors: a pictorial essay. BMC Med Imaging. 2022 Nov 7;22(1):191. doi: 10.1186/s12880-022-00924-0. PMID: 36344914; PMCID: PMC9641923.
Lee JH, Ostalecki C, Oberstein T, Schierer S, Zinser E, Eberhardt M, Blume K, Plosnita B, Stich L, Bruns H, Coras R, Vera-Gonzales J, Maler M, Baur AS. Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus. EBioMedicine. 2022 Mar;77:103903. doi: 10.1016/j.ebiom.2022.103903. Epub 2022 Feb 25. PMID: 35220044; PMCID: PMC8889140.
2021
Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. Nat Microbiol. 2021 Apr;6(4):467-478. doi: 10.1038/s41564-021-00884-1. Epub 2021 Mar 16. PMID: 33727702; PMCID: PMC8103894.
Han YJ, Zhang J, Lee JH, Mason JM, Karginova O, Yoshimatsu TF, Hao Q, Hurley I, Brunet LP, Prat A, Prasanth KV, Gack MU, Olopade OI. The BRCA1 Pseudogene Negatively Regulates Antitumor Responses through Inhibition of Innate Immune Defense Mechanisms. Cancer Res. 2021 Mar 15;81(6):1540-1551. doi: 10.1158/0008-5472.CAN-20-1959. Epub 2021 Jan 20. PMID: 33472891; PMCID: PMC7969461.
2020
Lee JH, Eberhardt M, Blume K, Vera J, Baur AS. Evidence for liver and peripheral immune cells secreting tumor-suppressive extracellular vesicles in melanoma patients. EBioMedicine. 2020 Dec;62:103119. doi: 10.1016/j.ebiom.2020.103119. Epub 2020 Nov 23. PMID: 33242827; PMCID: PMC7695971.
Schroeder C, Lee JH, Tetzner U, Seidel S, Kim SY. Comparison of diffusion-weighted MR imaging and 18F Fluorodeoxyglucose PET/CT in detection of residual or recurrent tumors and delineation of their local spread after (chemo) radiotherapy for head and neck squamous cell carcinoma. Eur J Radiol. 2020 Sep;130:109157. doi: 10.1016/j.ejrad.2020.109157. Epub 2020 Jun 30. PMID: 32652403.
2019
Riedl W, Acharya D, Lee JH, Liu G, Serman T, Chiang C, Chan YK, Diamond MS, Gack MU. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity. Cell Host Microbe. 2019 Oct 9;26(4):493-503.e6. doi: 10.1016/j.chom.2019.09.012. PMID: 31600501; PMCID: PMC6922055.
Lee JH, Dindorf J, Eberhardt M, Lai X, Ostalecki C, Koliha N, Gross S, Blume K, Bruns H, Wild S, Schuler G, Vera J, Baur AS. Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a. Life Sci Alliance. 2019 Mar 7;2(2):e201800205. doi: 10.26508/lsa.201800205. PMID: 30846484; PMCID: PMC6406044.
Lee JH, Chiang C, Gack MU. Endogenous Nucleic Acid Recognition by RIG-I-Like Receptors and cGAS. J Interferon Cytokine Res. 2019 Aug;39(8):450-458. doi: 10.1089/jir.2019.0015. Epub 2019 May 7. PMID: 31066607; PMCID: PMC6660835.
2018
Lee JH, Ostalecki C, Zhao Z, Kesti T, Bruns H, Simon B, Harrer T, Saksela K, Baur AS. HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles. EBioMedicine. 2018 Feb;28:151-161. doi: 10.1016/j.ebiom.2018.01.004. Epub 2018 Jan 4. PMID: 29331674; PMCID: PMC5836510.
2017
Ostalecki C, Lee JH, Dindorf J, Collenburg L, Schierer S, Simon B, Schliep S, Kremmer E, Schuler G, Baur AS. Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes. Sci Signal. 2017 Mar 14;10(470):eaai8288. doi: 10.1126/scisignal.aai8288. PMID: 28292959.
2016
Ostalecki C, Wittki S, Lee JH, Geist MM, Tibroni N, Harrer T, Schuler G, Fackler OT, Baur AS. HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection. EBioMedicine. 2016 Nov;13:294-304. doi: 10.1016/j.ebiom.2016.10.027. Epub 2016 Oct 19. PMID: 27773542; PMCID: PMC5264432.
Lee JH, Schierer S, Blume K, Dindorf J, Wittki S, Xiang W, Ostalecki C, Koliha N, Wild S, Schuler G, Fackler OT, Saksela K, Harrer T, Baur AS. HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection. EBioMedicine. 2016 Apr;6:103-113. doi: 10.1016/j.ebiom.2016.03.004. Epub 2016 Mar 3. PMID: 27211553; PMCID: PMC4856776.
BK21 supported members
-
지원
Woosung Shim
Project
: Research on the pathogenesis of HIV1
Anjae Lee
Project
: The relationship of SARS-CoV-2 and exosome secretion
-
참여
Hyukhee Kim
Project
: ZAP interacts with TRIM25 to improve the antiviral activity against HIV
